Need to ease indigestion pain? The brain has a direct effect on the stomach and intestines. A troubled intestine can send signals to the brain, just as a troubled brain can send signals to the gut. Therefore, a person's stomach or intestinal distress can be the cause or the product of anxiety, stress, or depression. That's because the brain and the gastrointestinal are intimately connected. Try following along and let me know if it eased your pain.